Day One

Explore the Agenda

Pre-Conference Day

Monday, 8th March

Day One

Tuesday, 9th March

Day Two

Wednesday, 10th March

Post-Conference Day

Thursday, 11th March

6:30 am Check In, Morning Coffee & Light Refreshments

7:30 am Chair’s Opening Remarks

Driving ADC Clinical Differentiation in an Increasingly Competitive & Crowded Market Towards Frontline Treatments

7:45 am Establishing Trastuzumab Deruxtecan in Residual Her 2 Positive Early Breast Cancer

Corina Taitt

Clinical Development Functional Excellence Head, Daiichi Sankyo

Presenting results from the Destiny Breast 05 programme
Outlining the safety profile of T-DXd
How to differentiate between radiation pneumonitis and drug-induced ILD

8:15 am Enhertu Now – The Power of the Patient Voice & Advocacy to Bring ADC Drugs to Frontline Treatments for Cancer

Kate Wills

Patient, Patient Advocate

8:30 am WuXiDARx™ Conjugation Technology & Proprietary Payload-Linker Platform: A Powerful Alliance for Next-Generation Dual Payload ADC Development

Marie zhu

Chief Technology Officer, WuXi XDC

Advancing next-generation dual-payload ADCs to address traditional challenges like drug resistance and narrow therapeutic windows
Leveraging WuXiDARx™ technology for flexible DAR1-6 and WuXiTecan2™ hydrophilic linker, enabling streamlined dual-payload construction without antibody engineering
Demonstrating a substantially wider therapeutic index alongside significantly enhanced anti-tumour efficacy in proof-of-concept studies

9:00 am CEO & ADC Pharma Leaders Think Tank: Solidifying Next-Generation ADCs as Standard of Care Therapies

Robert Lutz

Chief Scientific Officer, Iksuda Therapeutics

Dragan Grabulovski

CEO, Araris Biotech

Evelyn Fahrenkrug

Global Commercial Head Oncology Pipeline, Boehringer Ingelheim

David Simpson

CEO, Iksuda Therapeutics

Christian Rohlff

Chief Executive Officer & Founder, Oxford BioTherapeutics Ltd

Grzegorz Nowakowski

Senior Vice President, Head of Global Early Development Organization, Daiichi Sankyo

Caitlin Miller

Executive Director - Alzheimer’s Disease HCP Marketing, TwoStep Therapeutics

Outlining the latest trends across the ADC landscape in 2027 and future vision to develop and deliver novel ADCs with meaningful patient impact with safety and efficacy
Highlighting methods to best pursue ADC clinical differentiation across patient selection technologies, combination strategies, and well-executed clinical design
With clinical trials advancing in the Far East and Australia, what opportunities does this open for the ADC industry to progress faster?

9:45 am Morning Break & Structured Networking

Discovery Preclinical & Translational Clinical Lessons Process & Analytical Development Manufacturing & Supply Chain

Discovery

Discovery Track

Chair:

Matt Gray

Scientific Leader, GSK

Navigating Target Selection & Validation to Maximise ADC Potential at Discovery Stage

10:45 am Solidifying A New Class of ADC Targets from Discovery to the Clinic

Scott Lesley

President & Chief Scientific Officer, InduPro

Achieving target definition through proximity based co-targeting
Creating dual targeting TAPA ADCs to facilitate cell-selective therapeutic delivery
Demonstrating selectivity and efficacy over single targets

11:15 am Developing a Site-Specific & Versatile Conjugation Approach Based on Bacterial Transglutaminase & the Diels-Alder Cycloaddition Reaction

Francisco Velazquez

Senior Director, Chemistry, Abzena

Re-purposing maleimides for conjugation to antibodies, a different application that specifically conjugates via cycloaddition reaction
Exploring design and synthesis of diene-containing linkers for site-specific transglutaminase conjugation, with modulation for dual-payload ADCs
Evaluating in vitro and in vivo activity and assessing stability of ADCs

11:45 am Advancing Multi-Specific Drug Conjugates to Combat Tumour Heterogeneity & Resistance

Caitlin Miller

Executive Director - Alzheimer’s Disease HCP Marketing, TwoStep Therapeutics

Presenting the scientific rationale for a multi-specific targeting agent “PIP” and how it enables broad applicability across solid tumours
Preclinical development of PIP-drug conjugates, their efficacy and safety, and comparison to clinical benchmarks
Comparing the data from a single vs multi-targeted approach to highlight the rationale of multi-specific targeting

12:15 pm TME-Specific Payload Release: Discovery & Preclinical Validation of a Novel Enzyme-Cleavable Linker

Rene Hoet

Scientific Advisor, Nona Biosciences

Addressing tumour heterogeneity and drug penetration challenges with internalisation-independent payload release
Screening and identifying a unique linker using a specific TME enzyme expressed across cancer models for next-generation ADC development
Achieving superior efficacy and safety with an internalisation-independent linker-payload system in ductal and squamous carcinoma cell lines

Preclinical & Translational

Preclinical & Translation Track

Chair:

Jeremy Sauer

VP Strategy, Callio Therapeutics

Elevating ADC Preclinical Characterisation Across Translational Models to Better Predict Clinical Safety & Efficacy

10:45 am LCB43: A Next-Generation Beta-Glucuronide BCMA ADC for the Treatment of Multiple Myeloma

Matthew Sender

Director, LigaChem Biosciences

Belantamab Mafodotin is a great ADC held back by ocular toxicity
Sharing clinical evidence of less ocular toxicity
Addressing the key limitation of blenrep using LCB43, a next-generation ADC

11:15 am Translational Strategy to Evaluate ADC Efficacy & Overcome Payload-Specific Resistance Using Topo1- and Tubulin Inhibitor-Resistant PDX Models

Simon Jiang

Vice President of Strategy, Head of Scientific Engagement, LIDE Biotech

Assessing ADC efficacy through in vitro PDXO, MiniPDX, PDX models with data revealing resistance is driven by specific payload mechanism, independent of the target antigen
Validating rational combinations including ADC + IO therapy to overcome immunosuppressive resistance
Informing the design of next-generation ADCs, such as bispecific ADCs or dual payload conjugates, engineered to circumvent these resistance pathways

11:45 am Risk & Development Strategy to Bring Novel & First-in-Class ADCs to the Clinic

Elisabetta Leo

Senior Director, Early Development Asset Lead, Ipsen Pharma

Emphasising the importance of pursuing novel targets amongst a crowded clinical landscape
Contextualising learnings from progressing a novel target ADC to clinical trials to develop ADCs with meaningful patient impact
Incorporating learnings from historical profiles of adjacent target ADC: What are the indications of promising performance?

12:15 pm Target. Test. Treat: Patient-Derived Organoids Enable Smarter Evaluation of ADCs

Isabella Zampeta

Scientific Business Development Manager, HUB Organoids

PDOs act as functional ADC patient avatars, preserving tumour heterogeneity and normal tissue biology to reflect clinical efficacy and on-target/ off-target toxicity
PDOs capture variability in ADC response beyond antigen expression, enabling assessment of target engagement, internalisation, payload sensitivity, and tissue penetration
PDOs enable the development of next-generation therapeutic strategies, allowing for testing of combination therapies and comparison with SoC data in patient relevant models

Clinical Lessons

Clinical Lessons Track

Chair:

Rakesh Dixit

President & Chief Executive Officer, Bionavigen Oncology

Showcasing Promising ADC Clinical Development Reshaping Oncology Treatments Regiments

10:45 am JK06 Biparatopic 5T4-Targeted MMAE ADC: Overcoming the Challenges of a Difficult Target Through Rational Design

Samuel Murphy

Vice President & Head of International Business Development, Salubris Biotherapeutics Inc.

Reviewing target and molecule design rationale for a first-in-class quadrivalent, biparatopic ADC that selectively targets 5T4 with an MMAE payload
Outlining safety data and comparison with historical MMAE ADC safety data
Sharing efficacy data in solid tumours, NSCLC and breast cancer

11:15 am Group Discussion: Managing Clinical Safety & Improving Patient Outcomes in a Market of Crowded Indications

11:45 am Unveiling Novel ADC Designs that Drive Improved Clinical Outcomes

Robert Lutz

Chief Scientific Officer, Iksuda Therapeutics

Featuring an update on clinical progress for next-generation ADCs, IKS014 and IKS03
Differentiating programmes through ADC design to address competitive landscape
Spotlighting ADC innovation that is paving the way for novel payloads

12:15 pm Diving into the Next Wave of ADC Design

Yu-Shin Hsu

Senior Research Analyst, Beacon Intelligence

Reflecting on the technological advances and key development milestones of 2026 to uncover the trends shaping ADC innovation in 2027
Gaining exclusive insights into emerging target, payload, and technology trends across the next-generation ADC landscape
Exploring breakthrough conjugate innovations, from dual-payload and bispecific ADCs to AOCs and degrader drug conjugates

Process & Analytical Development

Process & Analytical Development Track

Chair:

Alain BECK

Senior Director, Biologics CMC and Developability, Pierre Fabre

Advancing Analytical Method Development for Complex ADC Characterisation & Quality Control

10:45 am Challenges in XDC Analytical & Functional Characterisation

Alain BECK

Senior Director, Biologics CMC and Developability, Pierre Fabre

XDCs are not a single modality but a family of highly diverse conjugate formats
The combination of different targeting moieties, linker chemistries, payload classes, and conjugation strategies generates substantial molecular heterogeneity that cannot be captured by traditional biologics characterisation approaches alone
Sharing case-studies of XDC attributes and development requiring integrated, orthogonal characterisation strategies that combine advanced analytics with functional assays

11:15 am Leveraging Bioconjugation Strategies to Enhance AOC CMC Processes

Navigating the nuances of AOC process development and understanding how to leverage physiochemical properties and chemistry aspects between different AOCs
Comparing AOCs with classical ADCs across payload complexity, impurity profiles, and essential analytical methods
Assessing the evolving regulatory framework, impurity control, stability, immunogenicity and target product profiles

11:45 am Multidimensional Analytical Solutions to Characterise Next Generation ADCs with Dual Payloads & Bispecific Formats

Bastiaan Duivelshof

Analytical Project Manager, Debiopharm

How can multidimensional chromatography setups help with the development of new complex ADCs?
Navigating characterisation challenges of dual payloads and bispecific ADC formats
Understanding payload distribution and complexity in dual-payload and bispecific ADCs

12:15 pm Accelerating the Development of Next-Generation Bioconjugate Drugs Through an Integrated Platform

Tiejun Li

Vice General Manager & Head, CMC & PM, AsymBio

Overviewing the challenges in bioconjugation CMC development for novel NDCs
Case study examples: Exploring strategies and fit for purpose solutions for complex bioconjugation processes development
Overviewing AsymChem/AsymBio’s integrated capabilities in NDC CDMO services

Manufacturing & Supply Chain

Manufacturing & Supply Chain Track

Chair:

Scaling Up Complex ADC Manufacturing from Lab to Commercial Scales

From Target to Clinic: Development & Manufacturing of the First in Class VARTUMAB ADC

Tobias Gustavson

Director - CMC Development, Var2 Pharmaceuticals

Oncofetal chondroitin sulfate, an abundant pan-cancer target present on cancer cells and in the tumour stroma
Selecting a monovalent scFv–Fc VARTUMAB ADC format, enabling a homogeneous DAR2 construct with deep tumour penetration and potent bystander activity
Highlighting GMP manufacturing and control of VARTUMAB ADC achieving high yield, purity and stability

11:15 am Evaluating Efficient Bioburden Control From Drug-Linker to ADC Drug Substance

Melanie Derde

Head of bioconjugation operations, Axplora

Navigating a holistic and risk-based approach for both drug-linker and ADC drug substance process
Exploring a case study of environmental monitoring of drug linker and ADC drug substance facilities
Using case study examples to assess drug-linker and ADC microbial methods

11:45 am From Mushroom to Clinic: Establishing Total Synthesis & CMC Infrastructure for Amanitin-Based ADCs

Christian Lutz

Senior Director CMC, Heidelberg Pharma

Establishing total synthesis methods for amanitin-based ADCs
Overcoming process development and manufacturing infrastructure challenges
Achieving effective clinical supply and ancillary qualifications

12:15 pm Breaking Down ADC Manufacturing Strategy & Solutions

Lena Jonsson

Product Strategy Manager, Cytiva

Discussing tools used for efficient and scalable manufacturing of the mAb intermediate, a key starting point for ADC conjugation
Highlighting various chromatography systems and resins used in the process, such as the ÄKTA™ systems and MabSelect PrismA™ resin, designed for robustness and efficient purification
Presenting the compatibility of materials in single-use systems with solvents used in ADC manufacturing process, detailing the steps involved in analysis

1:00 pm Lunch & Learn Session Presentation Hosted By Proveo

Invitation-only session. For all other attendees, lunch is provided in the exhibition area

Discovery Preclinical & Translational Clinical Lessons Process & Analytical Development Manufacturing & Supply Chain

Discovery

Redefining ADC Performance in the Clinic Through Novel Payloads & Linker Discoveries

1:45 pm Unlocking a Novel ProAlk Linker Payload Technology to Overcome ADC Payload Resistance Challenges

Jutta Deckert

Vice President, R&D, Iksuda Therapeutics

Addressing resistance to current payloads with novel ADC payload development
Setting linker-payload criteria and integrating learnings from failed molecules to improve ADC designs
Highlighting challenges in preclinical evaluation to progress a new payload into development

2:15 pm Contrasting Discovery & Preclinical Head-to-Head Comparison of Two ADCs

Hua Yang

Chief Scientific Officer, Pharmaron

Comparing SG and Dato-DXd with pH-sensitive and protease-specific linkers, respectively
Assessing how linker-driven payload release influences efficacy, in vitro and in vivo bystander effects, dosing, and safety
Completing physicochemical, structural, in vitro, in vivo, DMPK, and toxicology assessment

2:45 pm Next-Generation ADCs: Advancing Targeted Cancer Therapy

Paul Jackson

Chief Operating Officer, Adcytherix

Developing next-generation ADCs designed to overcome resistance to current ADC therapies
Leveraging innovative payloads and advanced conjugation strategies to enhance efficacy and expand the therapeutic window
Translating novel ADC technologies into differentiated therapies for patients with high unmet need

Preclinical & Translational

Advancing Dual-Payload ADCs: From Computational Design to Clinical Translation

1:45 pm Harnessing the Potential of Dual Payload ADCs Across Disease Areas with AI-first Approach to ADCs

Jerome Boyd-Kirkup

Chief Scientific Officer & Co-Founder, Hummingbird Bioscience

AI-first, engineering-led approach to drug discovery and development underpins our dual-payload ADC technology
Applying AI-guided payload selection to rationally combine complementary biological mechanisms for distinct therapeutic challenges
Integrating computational linker optimisation, site-specific conjugation and stable linker chemistry with scalable, manufacturable design to optimise efficacy, minimise off-target toxicity and accelerate differentiated ADC candidates from design to the clinic

2:15 pm Group Discussion: Modelling PK/PD of Novel ADCs to Overcome Binding Site Barriers & Penetration with Translatability into Humans

2:45 pm GQ1035: A First-in-Class Dual Payload ADC with Promising Preclinical Activity in Gastric Cancer

Paul Song

Chief Scientific Officer, Genequantum Healthcare

Addressing unmet therapeutic needs in gastric cancer through a novel dual payload ADC strategy
Demonstrating promising anti-tumour activity across multiple patient-derived xenograft (PDX) models of gastric cancer
Translating preclinical efficacy and emerging biomarker insights into indication selection and future clinical development

Clinical Lessons

Redefining ADC Clinical Development Through Novel Biology & Proof-of-Concept Studies

1:45 pm From Immuno-PET to Phase 1: Translating VARTUMAB Oncofetal Chondroitin Sulfate Targeting into an ADC Therapy

Ali Salanti

CEO, Professor, Var2 Pharmaceuticals

Demonstrating effective tumour knockdown through targeting oncofetal chondroitin sulfate across cancer cells, circulating tumour cells, and tumour stromal cells
Achieving clinical validation of tumour targeting by immuno-PET in 16 cancer patients
Spotlighting GLP toxicology and Phase 1 clinical trial design

2:15 pm Group Discussion: Designing Optimal Biomarker Strategies from IHC to Radiology to Identify Suitable Responders in Heterogeneous Populations & Adapting Trial Design

2:45 pm Enhancing the Therapeutic Potential of Topoisomerase Inhibitor ADCs: From Concept to Clinical Validation

Paul Moore

Chief Scientific Officer, Zymeworks

Learnings from 40+ years of ADC clinical development guiding ZD06519 Topo1i linker-payload design
Presenting Phase 1 clinical proof of concept studies with ZW191, supporting a potential best-in-class Folate receptor alpha targeting ADC
Applying ZD06519 to additional targets/ antibody formats to expand tumour type coverage and address target/tumour specific biology

Process & Analytical Development

Optimising ADC Manufacturing Through Smarter Process & Impurity Control

1:45 pm A Justified Limit for the Identification Threshold of Organic Impurities in Drug-Linker Intermediates Used to Produce Antibody-Drug Conjugates

Osama Charhrour

Principal Scientist - New Modalities, AstraZeneca

Showcasing a science-based justification for D-L related impurities identification threshold
Analysing a 47-ADC data set to justify the proposal of related impurities identification threshold
Applying four independent quantitative criteria to address what impurity levels are all four criteria satisfied for all 47 clinical-stage ADCs in our dataset

2:15 pm Session Reserved for Simtra BioPharma Solutions:

2:45 pm Evaluating the Conjugatability of ADC Drug-Linker Impurities to Develop Process & Impurity Control Strategies

Etsushi Yoshikawa

Scientist, Astellas Pharma

Highlighting the importance of evaluating the “conjugatability” of drug linker-derived impurities
Demonstrating the use of LC-MS/MS and derivatization to efficiently assess impurity conjugatability without full structural identification
Illustrating how conjugatability assessment can provide scientific insights to develop process optimisation and impurity control

Manufacturing & Supply Chain

Tackling the Considerations & Challenges for ADC Supply

1:45 pm Navigating the Conjugation Tightrope: Successful PPQs in Complex ADC Outsourcing

Jeroen Janssens

Director Technical Operations, Merck & Co

Accelerated development can mean process characterisation and control strategies continue evolving between engineering and PPQ batches. Strong scale-down models, input-material control, rapid data sharing, and close CMO collaboration become key enablers
ADCs bring together a mAb, linker, and highly potent payload, often across 4–5 manufacturing/testing sites, making specifications, comparability, supply coordination, cost, and timelines critical
Successful tech transfer requires integration of two different technical worlds, with particular attention to conjugation process robustness, analytical methods, scale-up, containment/EHS, and cross-functional ways of working

2:15 pm Session Reserved for MabPlex:

2:45 pm Reimagining ADC Manufacturing: Driving Simplicity, Scalability & Supply Chain Efficiency

Olivier Marcq

Executive Director, Gilead Sciences

Compare clinical and commercial ADC manufacturing processes alongside emerging conjugation technologies to assess process and supply-chain complexity
Exploring opportunities for continuous manufacturing, including barriers to industry adoption
Reviewing insights on the performance, scalability, and stability of ADCs across multiple clinical programmes

3:15 pm Afternoon Break, Networking & Poster Session

Trailblazing Chinese ADC Payload Innovation from Concept to Clinic to Develop Safer & More Efficacious ADC Therapies

4:15 pm Over the Horizon: Demonstrating Dual Payload Innovation

Min Hu

Senior Vice President, Oncology Discovery, Innovent Biologics

Highlighting the progress of dual payloads and identifying the unmet needs in ADC field
Unlocking emerging targets and payload the landscape
Showcasing the evolution of ADC technology

4:45 pm Improving ADC Quality & Manufacturing While Cutting Programme Costs to Accelerate ADC Development to Patients

Fabrizia Minandri

Technology Transfer Manager, Large Molecule ADCs Platform, BSP Pharmaceuticals

Advancing ADC development through cost-effective solutions
Driving ADC success with flexible and high-quality solutions from preclinical to commercial development
Ensuring right first-time-approved regulatory submission to save time and costs bringing ADCs to patients in need

5:15 pm Showcasing Phase 1/2a Open-Label Clinical Trial Results Evaluating VBC103, a Nectin-4 & TROP2 Targeted Bi-Specific ADC in Participants with Advanced Solid Tumour Malignancies

Jing Li

Founder and CEO, VelaVigo

Leveraging an internal R&D engine for consistent delivery of ADC programmes
Designing a novel dual-targeting bispecific ADC that simultaneously targets Nectin-4 and TROP2
Showcasing Phase 1/2a open-label clinical trial results evaluating VBC103 in participants with advanced solid tumour malignancies

5:45 pm Harnessing GlycoConnect® Technology for Best-in-Class ADCs: Emerging Clinical Insights

Anette Sommer

Head Bioconjugates Research, Lonza

Exploring how GlycoConnect® and HydraSpace® technologies enable ADCs with best-in-class therapeutic potential
Sharing clinical development insights on the rapidly expanding and advancing pipeline of GlycoConnect® technology-based partnered ADC assets
Discussing technology expansion towards high-DAR and dual-payload ADCs

6:15 pm Unveiling Non-Internalizing ADC: Linker-Payload Technologies & Clinical Products

Jiaqiang Cai

Co-founder ,Chief Scientific Officer & Co-Chief Executive Officer, Medilink Therapeutics

Highlighting current non-internalizing ADC linker-payload technologies and its challenges
Demonstrating in vitro and in vivo mechanistic studies with TMALIN ADC technology
Sharing clinical product examples from TMALIN linker-payload technology to achieve better efficacy, low toxicity and a bigger ADC target space

6:45 pm Chair’s Closing Remarks

As the landscape of innovation is supercharging the next wave of ADC drug development, it is more important than ever to collaborate and learn for the growth of this field. Enjoy an informal end to the busiest conference day with a drink and join our dedicated poster session to share your latest data and make new connections as you discuss your ADC learnings and 2027 objectives.

6:50 pm Scientific Poster Session & Drinks Reception

7:50 pm End of Conference Day One

Explore the Agenda

6:30 am Check In, Morning Coffee & Light Refreshments

7:30 am Chair’s Opening Remarks

Driving ADC Clinical Differentiation in an Increasingly Competitive & Crowded Market Towards Frontline Treatments

7:45 am Establishing Trastuzumab Deruxtecan in Residual Her 2 Positive Early Breast Cancer

8:15 am Enhertu Now – The Power of the Patient Voice & Advocacy to Bring ADC Drugs to Frontline Treatments for Cancer

8:30 am WuXiDARx™ Conjugation Technology & Proprietary Payload-Linker Platform: A Powerful Alliance for Next-Generation Dual Payload ADC Development

9:00 am CEO & ADC Pharma Leaders Think Tank: Solidifying Next-Generation ADCs as Standard of Care Therapies

9:45 am Morning Break & Structured Networking

Discovery Track

Chair:

Navigating Target Selection & Validation to Maximise ADC Potential at Discovery Stage

10:45 am Solidifying A New Class of ADC Targets from Discovery to the Clinic

11:15 am Developing a Site-Specific & Versatile Conjugation Approach Based on Bacterial Transglutaminase & the Diels-Alder Cycloaddition Reaction

11:45 am Advancing Multi-Specific Drug Conjugates to Combat Tumour Heterogeneity & Resistance

12:15 pm TME-Specific Payload Release: Discovery & Preclinical Validation of a Novel Enzyme-Cleavable Linker

1:00 pm Lunch & Learn Session Presentation Hosted By Proveo

Redefining ADC Performance in the Clinic Through Novel Payloads & Linker Discoveries

1:45 pm Unlocking a Novel ProAlk Linker Payload Technology to Overcome ADC Payload Resistance Challenges

2:15 pm Contrasting Discovery & Preclinical Head-to-Head Comparison of Two ADCs

2:45 pm Next-Generation ADCs: Advancing Targeted Cancer Therapy

3:15 pm Afternoon Break, Networking & Poster Session

Trailblazing Chinese ADC Payload Innovation from Concept to Clinic to Develop Safer & More Efficacious ADC Therapies

4:15 pm Over the Horizon: Demonstrating Dual Payload Innovation

4:45 pm Improving ADC Quality & Manufacturing While Cutting Programme Costs to Accelerate ADC Development to Patients

5:15 pm Showcasing Phase 1/2a Open-Label Clinical Trial Results Evaluating VBC103, a Nectin-4 & TROP2 Targeted Bi-Specific ADC in Participants with Advanced Solid Tumour Malignancies

5:45 pm Harnessing GlycoConnect® Technology for Best-in-Class ADCs: Emerging Clinical Insights

6:15 pm Unveiling Non-Internalizing ADC: Linker-Payload Technologies & Clinical Products

6:45 pm Chair’s Closing Remarks

6:50 pm Scientific Poster Session & Drinks Reception

7:50 pm End of Conference Day One

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