Jutta Deckert
Seminars
Tuesday 9th March 2027
Unlocking a Novel ProAlk Linker Payload Technology to Overcome ADC Payload Resistance Challenges
1:45 pm
- Addressing resistance to current payloads with novel ADC payload development
- Setting linker-payload criteria and integrating learnings from failed molecules to improve ADC designs
- Highlighting challenges in preclinical evaluation to progress a new payload into development
Thursday 11th March 2027
Leveraging Clinical Outcomes & Performance to Inform the Development of Novel ADC Design
1:00 pm
This workshop will focus on improving translatability of pre-clinical findings to first-in human studies that maximise learning while ensuring patient safety. It will be an opportunity to discuss back-translation strategies to inform next-generation ADC design.
Key Questions:
- Which ADC designs signify the best clinical efficacy and outcomes by overcoming resistance challenges?
- How do we establish human dose projections from pre-clinical studies?
- What can we learn from clinical failures to improve current ADC designs?
