Francisco Velazquez
Seminars
Tuesday 9th March 2027
Developing a Site-Specific & Versatile Conjugation Approach Based on Bacterial Transglutaminase & the Diels-Alder Cycloaddition Reaction
11:15 am
- Re-purposing maleimides for conjugation to antibodies, a different application that specifically conjugates via cycloaddition reaction
- Exploring design and synthesis of diene-containing linkers for site-specific transglutaminase conjugation, with modulation for dual-payload ADCs
- Evaluating in vitro and in vivo activity and assessing stability of ADCs
