Rene Hoet
Seminars
Tuesday 9th March 2027
TME-Specific Payload Release: Discovery & Preclinical Validation of a Novel Enzyme-Cleavable Linker
12:15 pm
- Addressing tumour heterogeneity and drug penetration challenges with internalisation-independent payload release
- Screening and identifying a unique linker using a specific TME enzyme expressed across cancer models for next-generation ADC development
- Achieving superior efficacy and safety with an internalisation-independent linker-payload system in ductal and squamous carcinoma cell lines
