Explore the Agenda
7:30 am Check In, Morning Coffee & Light Refreshments
8:25 am Chair’s Opening Remarks
Tackling the Necessity for Bioconjugate Design & Payload Innovation to Secure the Future of ADCs as Clinically Meaningful Oncology Therapies
8:30 am Fuelling the Next Generation of ADCs: Protein Alkylation Payloads & the Broader ADC Innovation Imperative
- Highlighting the strategic need for diversified payload platforms to drive sustainable ADC pipeline growth and maintain market competitiveness
- Positioning protein alkylation as a differentiated and emerging modality within the evolving ADC payload landscape
- Showcasing the unique mechanism of action and therapeutic potential of Iksuda Therapeutics’ ProAlk™ payload
9:00 am Synaffix/Lonza End-to-End Offering to Best-in-Class Targeted-Therapies Based on GlycoConnect® & HydraSpace® Technologies
- Exploring how GlycoConnect® and HydraSpace® technologies enable ADCs with best-in-class therapeutic potential
- Sharing clinical development insights on the rapidly advancing pipeline of GlycoConnect® ADCs by partners
- Discussing technology expansion towards bispecific (bYlok®) and dual warhead ADCs with compelling in vivo data
- Presenting unprecedented mRNA exon skipping and dystrophin restoration in preclinical mouse model for Duchenne muscular dystrophy
9:30 am Spotlighting Efficacy & Safety Profiles of Dual Payload ADCs Featuring Novel Linker Payloads to Overcome Resistance Mechanisms
- Exploring rationale for dual payload ADCs, combining synergetic efficacy of Topo1 payloads combined with diverse, alternative mechanisms to overcome patient resistance
- Spotlighting comprehensive preclinical efficacy of dual payload ADCs across in vitro and in vivo models
- Supporting promising efficacy results with preclinical pharmacology, PK/PD and safety profiles of dual cytotoxic conjugate
10:00 am Managing High-Potency & Environmental Priorities Through Sustainable Practices in Complex API Manufacturing
- Enacting innovative approaches to implement the Green Chemistry concept to ADC manufacturing
- Developing clinical to commercial phase manufacturing processes to achieve improvement goals for environmental impact, safety, and economic value
- Managing the supply chain for sustainable and reliable complex HPAPI and ADC manufacturing
10:30 am Morning Break & Networking
Scientific posters will be displayed all day. Use this dedicated time to meet poster authors and ask your burning questions
Discovery
Preclinical & Translational
Clinical Lessons
Process & Analytical Development
Manufacturing & Supply Chain
Discovery
Discovery
Exploring Rationale-Driven Approaches to Deliver ADC Payload & Target Differentiation
11:30 am Showcasing Tubulin Inhibitor Payload Innovation to Develop Novel ADCs & Subvert Patient Resistance to Established Mechanisms
Chief Executive Officer, Oxford BioTherapeutics
- Weighing up novel payload development through evolving existing payload classes versus pursuing novel mechanisms
- Leveraging new and advanced tools to investigate novel tubulin payload development
- Contextualising payload innovation through ADC programmes and understanding significance for nextgeneration ADC development
12:00 pm Blending Chemistry & Biology ADC Design: Exploring Rationale- Driven Development of ALX2004 to Maximise Opportunity for Clinical Differentiation
Vice President, Antibody Technologies, ALX Oncology
- Highlighting design and selection of novel Topo1 payload, highlighting rationale for pairing with anti-EFGR antibody
- Presenting preclinical performance of ALX2004 including activity with improved bystander activity and stability versus deruxtecan ADCs
- Sharing rationale and design to maximise therapeutic window and overcome toxicity challenges of the class
12:30 pm Session Presented By LICOR bio
Preclinical & Translational
Clinical Lessons
Process & Analytical Development
Manufacturing & Supply Chain
1:00 pm Lunch & Learn Session Presentation Hosted By Merck
Invitation-only session. For all other attendees, lunch is provided in the exhibition area
Discovery
Preclinical & Translational
Clinical Lessons
Process & Analytical Development
Manufacturing & Supply Chain
Discovery
Utilising Novel Conjugation Chemistries to Enhance ADC Properties & Widen Therapeutic Index
2:00 pm Exploring a Comparative Study of Click Handle Stability in Common Ligation Conditions to Improve ADC Experimental Design
Senior Scientist, GSK
- Discussing click chemistry approaches for ADC synthesis
- Assessing the compatibility of reagents used within click reactions with common conjugation conditions
- Discussing lessons learned to guide selection of the most optimal combination of click chemistry and conjugation to streamline ADC experimental design
2:30 pm Summary Panel Discussion: What ADC Discovery Innovation is Showing the Most Promise
Consultant, Independent Consultant
Re-join the discovery speakers for a closing panel discussion exploring the future directions of ADC discovery innovation. Engage with fellow attendees as they discuss novel payload trends, potential for payload combinations to overcome patient resistance, and the benefits of bispecific conjugates alongside classical ADC design.
Preclinical & Translational
Clinical Lessons
Process & Analytical Development
Manufacturing & Supply Chain
3:00 pm Afternoon Break & Networking
Showcasing Innovative ADC Design Philosophy to Elevate ADC Efficacy & Tolerability & Widen Therapeutic Index
4:00 pm Undergoing Kinder & Gentler ADC Development to Unlock Next-Generation, Earlier Line Patient Therapies
- Contextualising lessons learned from the current ADC clinical development landscape and advocating for an enhanced focus on addressing tolerability to improve ADC performance and success for patients
- Pursuing less toxic ADC development to evolve dosing to be equivalent to naked antibody therapies and expand therapeutic index
- Highlighting differentiation strategy for kinder and gentler ADC development, headlined with preclinical profile of KIVU-107 against solid tumours
4:30 pm Next-Generation Bioconjugate Therapeutics: Driving Innovation With Revolutionary Conjugation Technologies
- Overviewing GeneQuantum’s holistic conjugation and manufacturing platforms: iLDC and iGDC
- Introducing the world’s first rapid ADC screening system: iScreener
- Empowering best-in-class and first-in-class XDC therapeutic development through GeneQuantum’s leading technology platform
5:00 pm CX-2051: Unlocking EpCAM as a Cancer Target via a Masked EPCAM-Directed Topo1 ADC
- EpCAM is highly and uniformly expressed in CRC, but its normal tissue expression has precluded targeting EpCAM with systemic therapies
- Introducing CX-2051 as a first-in-class masked EpCAM targeted Topo1 ADC with compelling preclinical profile and early Phase I data
- CX-2051 is being rapidly advanced in the clinic in CRC with a path to expanding to other EpCAM expressing solid tumours