Hanspeter Gerber
Seminars
Wednesday 10th March 2027
Panel Discussion: Trailblazing Next-Generation of ADCs from XDCs to Dual Payload Innovation to Develop Safer & More Efficacious ADC Drugs from Concept to Clinical Validation
9:30 am
- Debating the optimal chemical and biological properties of next-generation payload and linker combinations
- Exploring the novelty of dual-payload ADCs and their potential to overcome resistance and improve safety profiles compared to traditional ADCs
- Assessing the potential of novel ‘XDC’ candidates to expand therapeutic applications and unlock untapped opportunities within an increasingly crowded ADC landscape
Wednesday 10th March 2027
STRO-004 Clinical Learnings: How ADC Design Shapes Safety & Efficacy
4:45 pm
- Tracing STRO-004’s development from antibody engineering and linker–payload design to its potential clinical differentiation among ADC therapies
- Presenting new Phase I safety and pharmacokinetic data for tissue factor–targeted STRO-004, including translation from cynomolgus monkey studies and implications for therapeutic index
- Examining the design rationale and development of dual-payload ADCs to address resistance to single-payload therapies.
