Explore the Agenda

8:00 am Check In, Morning Coffee & Light Refreshments

Workshop A

Workshop A

Tailored to Discovery Content

9:00 am Examining The Need for Novel ADC Payload Mechanisms: What Progress Has Been Made & What is Yet to be Demonstrated?

Principal Scientist, Roche
Executive Director & Head, R&D France, Eli Lilly & Co.

As the ADC landscape becomes busier and more crowded around validated Topo1 and MMAE payloads, the need for differentiated mechanisms is vital to ensure future conjugates can overcome anticipated resistance and deliver patient benefit

Join this workshop session to navigate the different avenues of novel payload development, assessing the emerging performance of cytotoxic, non-cytotoxic and dual payload approaches to discuss and debate the next payload wave to replace topoisomerase inhibitors

Workshop highlights include:

  • Discussing the crucial need for novel ADC payloads in the face of crowded clinical landscapes and future patient resistance mechanisms
  • Weighing up risk level against novelty of mechanism when approaching novel payload development: What linker payloads are showing the most promise so far?
  • Evaluating the opportunity for dual payload ADCs and combination therapies to combat patient resistance
Workshop B
Workshop C
Workshop D

12:00 pm Lunch & Networking

Workshop E

Workshop E

Tailored to Discovery Content

1:00 pm Deep Diving into ADC Chemistry Conjugation to Understand the Fundamentals Behind Next-Generation ADC Properties & Design

Distinguished Scientist, Discovery Chemistry, MSD

Understanding the challenges and opportunities at the forefront of ADC conjugation is vital to optimise ADC design, DAR and therapeutic properties capabilities from the get-go

Join this workshop to secure your understanding of fundamental principles of ADC conjugation, assess the pros and cons of next-generation site-specific technologies and explore how best to approach conjugation design with clinical differentiation in mind

Workshop highlights include:

  • Delving into ADC bioconjugation: What is the chemistry behind building ADCs?
  • Assessing the pros and cons of different conjugation methods across sitespecific and click chemistries, including biorthogonal methods
  • Breaking down the foresight and innovation during discovery to maximise differentiated ADC performance in the clinic
Workshop F
Workshop G
Workshop H

4:00 pm End of Post Conference Workshop Day