Post-Conference Workshop Day
Friday, 15th March 2024
Pick Your Two Favourite
9:00 am
Morning Workshop Sessions
Workshop A
Precision Pointing: Discovering & Evaluating Novel Targets
Offering a comprehensive overview of identifying disease-specific antigens, evaluating antigen expression, and understanding internalization and processing, this session will strategise ways to optimise ADC target selection using modern methodologies and technologies.
This workshop will:
• Identify disease-specific antigens and evaluate their expression
• Explore antigen internalisation and processing
• Grasp the importance of target density, antigen distribution, and heterogeneity
• Comprehend the role of immune modulation and biomarkers
• Look at practical application through real-world case studies
• Discuss novel technologies and methodologies for ADC target optimization
Workshop Leaders:
Gilles Gallant, Chief Development Officer, Mythic Therapeutics
Gladys Morrison-Thiele, Associate Director Clinical Science Oncology Development, AbbVie
1:00 pm
Afternoon Workshop Sessions
Workshop B
Breaking Boundaries: Unravelling the Secrets of ADC Linker Discovery
Centring on the critical role of linkers in ADCs, deep-dive into the nuances of cleavable and non-cleavable linkers, investigate their differential impacts across diverse cancer cells within a tumour, and explore pre-targeting strategies with staggered linker dosage for optimised ADC efficacy and reduced side effects.
This workshop will:
• Compare and contrast cleavable and non-cleavable linkers, including their stability, toxicity, and therapeutic index
• Discuss cleaving rate dynamics in ADCs and whether it correlates with efficacy
• Shed light on innovative pre-targeting strategies using staggered dosage of ADC linkers to enhance efficacy and mitigate side effects
Workshop Leader:
Xiaona Jing, Vice President Global Product Development, Multitude Therapeutics
Sunny-Zhou, Professor, Northeastern University School of Science