7:30 am Check In, Morning Coffee & Light Refreshments
8:20 am Chair’s Opening Remarks
Evaluating Novel ADC Formats & Payloads in the Clinic – How Do They Perform Against Classical ADCs?
8:30 am Investigating the Clinical Performance of Zelenectide Pevedotin & BT5528 to Understand Class Effect Differences of Bicycle Toxin Conjugates Against Classical ADC Formats
Synopsis
• Laying out the emerging safety profiles of zelenectide pevedotin and BT5528, and comparing toxicity characterisation against classical ADC formats
• Delving into BT5528 clinical toxicity profile against EphA2 in contrast to ADCs against the same target
• Rationalising preclinical and clinical differences with PKPD analysis and understanding the advantages of BTCs design and performance
9:00 am Versatile & Robust Chemical Site-Specific Conjugation Platform: AJICAP® Technology
Synopsis
• AJICAP® Conjugation: Examining how site-specific technologies are being employed in many of the next-generation ADCs due to the enhancement of clinically relevant biological properties observed in various preclinical studies
• AJICAP® Linker: Demonstrating a novel hydrophilic linker technology that enables the versatile synthesis of homogenous DAR = 1, 2, 4, 8, and higher
• Showcasing bispecific and trispecific antibodies produced by a fully chemical conjugation technology
9:30 am Detailing Clinical Development of OncoFAP: a Small Molecule Conjugate Targeting Fibroblast Activation Protein in Solid Tumours
Synopsis
• Exploring ongoing OncoFAP tumour target activity in first-in-human imaging studies in solid tumours
• Assessing OncoFAP anti-tumour response as a monotherapy and in combination with immunotherapies
• Contrasting anti-cancer properties of small-molecule conjugates against antibody-drug conjugates
10:00 am Advantages of Clinical Stage GlycoConnectTM Platform Technology – Successful Application for Multiple Targets & with Different Payload Classes
Synopsis
• GlycoConnectTM, HydraSpace® and toxSYN® technologies enable ADCs with best-in-class therapeutic index potential
• Updates on the rapidly advancing pipeline of GlycoConnectTM ADCs by partners
• Clinical development insights on the most advanced assets
10:30 am Scientific Poster Session Two
Synopsis
Keep the ADC innovation and networking going with the second scientific poster session, with brand-new posters available to discuss and debate! Rejoin your peers to continue the face-to-face time learning and stay informed on the cutting-edge work being carried out by your industry peers.
Discovery
Chair: Lenka Sadilkova, Director, Non-Clinical Projects, Mablink
Bioscience, an Eli Lilly Subsidiary
Download the Full Event Guide for full details
Showcasing Challenges & Opportunities in Novel Conjugate Design & Development
11.30 am Bispecific & Biparatopic Antibody Drug Conjugates: Evaluating Strategies & Challenges
• Exploring BpAbs and BpADCs MoA beyond classical antibodies
such as enhanced avidity binding, locking receptor conformation, faster internalisation and payload delivery to low cancer cell populations
• Engaging multiple antigens and cells simultaneously by bispecific ADCs to elicit synergistic effects such as killing a broader spectrum of tumour cells and promoting payload uptake
• Discussing BpADCs and BsADCs design and formats, target and linkerpayload selections, clinical status and limitations
Alain Beck, Senior Director, Biologics CMC Developability, Pierre Fabre
12.00 pm Targeting TYRP-1 in Malignant Melanoma: Novel mavg-MMAU Linker-Payload Improves Both Efficacy & Tolerability of Auristatin ADCs
• Explore how TYRP-1 is a novel ADC target for malignant melanoma
• Discuss the hydrophilic and potent auristatin payload MMAU was superior to topo 1 and topo 2 inhibitors as an anti-TYRP-1 ADC payload
• Learn about the novel mavg-MMAU linker-payload with high systemic and metabolic stability had superior therapeutic window compared to vedotin
• Developing DAR4 and DAR8 mavg-MMAU ADCs against solid and heme malignancies
Juhani Saarinen, Chief Executive Officer, Glykos Finland Oy
12.30 pm Session Presented by
1.00 pm Lunch & Learn Sessions Presented by
Innovating Linker Chemistry to Widen Applications & Maximise Tumour Payload Delivery
2.00 pm Broad-Spectrum Efficacy of CEACAM6-Targeted ADC With BET Protein Degrader
• Developing a novel ADC targeting CEACAM6 with BET protein degrader
• Demonstrating potent and in broadspectrum efficacy in CRC,
BC, and LC models
• Discussing combination therapy effects with immune checkpoint inhibitors
Hiroyuki Kogai, Scientist, Eisai
2.30 pm Leveraging Glycan Linker Chemistry & Site-Specific Conjugation to Improve ADC Performance
• Understanding the current limitations of linker chemistry on ADC properties
• Considering the biophysical characterisation of ADCs with different linker design and conjugation site
• Discussing how glycan site-specific conjugation can improve the performance of ADCs
David Huang, Head, Medicinal Chemistry,OBI Pharma
3.00 pm Linker-Payload Design & ADC Human MTD: Progressing from Chemistry to the Clinic
• Evaluating T-moiety linkers for hydrophobic payloads e.g. exatecan to overcome resistance and expand the therapeutic window of ADCs
• Explaining implications of liker chemistry in preclinical in vivo efficacy and safety
• Contextualising impact on human MTD from ongoing clinical studies
Xiaona Jing, Senior Vice President, Global Product Development & Partnering, Multitude Therapeutics
3:30 pm Afternoon Break & Networking
Leveraging Biomarkers & Diagnostic Tools to Inform Patient Selection Strategies for Precision Medicine ADC Development
4:00 pm Targeted Cancer Therapy for Patients With 17p Deletion
Synopsis
• Breaking down clinical profile and new phase I escalation data of HDP-101 targeting BCMA in myeloma patients
• Laying out retrospective analysis and investigation in deletion models of 17p deletion as a biomarker and patient selection tool for amanitin payload ADCs
• Discussing future directions for clinical development and potential for patient selection investigation for precision medicine ADC development
4:30 pm Panel Discussion: Evaluating the Need for Biomarker & Patient Selection Tools in an Increasingly Busy ADC Field: What are the Predictions for Future ADC Precision Medicine Approaches?
Synopsis
• What is the current need and appetite for ADC biomarker development and patient selection strategies heading into 2025?
• Discussing the different methodologies across machine learning and digital pathology to quantify IHC derived ADC target expression
• Addressing the challenges and opportunities of biomarker analysis to select patient populations to benefit from specific ADCs
• Summarising future predictions for precision medicine ADC development