Development of a Site Specific & Versatile Conjugation Approach Based on Bacterial Transglutaminase & the Diels-Alder Cycloaddition Reaction

• Re-purposing maleimides for conjugation to antibodies, a different application that specifically conjugates via cycloaddition reaction
• Exploring design and synthesis of diene-containing linkers for site-specific transglutaminase conjugation, with modulation for dual-payload ADCs
• Evaluating in vitro and in vivo activity and assessing stability of ADCs
• Highlighting the importance of collaborations with CROs for discovering and developing novel linker and conjugation technologies

Speakers:

Francisco Velazquez

Senior Director, Chemistry

Abzena