Stefano Zanotti
Senior Vice President & Head, Neuromuscular Research Dyne Therapeutics
Stefano Zanotti, Ph.D. heads the Neuromuscular Research department at Dyne Therapeutics, where he oversees a multidisciplinary research team dedicated to advancing Dyne pipeline by discovering and developing treatments for rare neuromuscular diseases. Stefano has committed his career to rare genetic disorders; prior to joining Dyne, he was Director of Rare Renal and Musculoskeletal Diseases at Sanofi where he led multiple research programs in rare disease indications. Before transitioning to industry, Stefano was an Assistant Professor at the University of Connecticut School of Medicine, where he conducted NIH-funded research focused on the role of Notch signaling on genetic disorders of the skeletal system. Stefano has published numerous reviews, book chapters, and more than 50 research articles in major scientific journals. He has presented his research at international scientific congresses and has been awarded multiple honors for his contributions to the field of skeletal biology. Stefano is also an inventor on several patents in the field of oligonucleotide design and targeted drug delivery.
Seminars
- Exploring the FORCETM modular drug delivery approach to enable widespread distribution of AOCs and chemically diverse therapeutic payloads to muscle and the CNS
- Assessing clinical data from DYNE-101 ACHIEVE trial in patients with DM1 and DYNE-251 DELIVER trial against DMD
- Contextualising how the encouraging clinical data and preclinical efficacy in FSHD and Pompe models supports the potential of FORCETM and AOCs to address neuromuscular disorders with high unmet medical needs
