Diana Hudecz
Senior Scientist SOTIO Biotech a.s.
Diana has over 10 years of experience in drug discovery and development. She currently works as a Senior Scientist at SOTIO Biotech, where she leads in vitro activities supporting the preclinical development of ADCs. Her previous research focused on the trafficking and delivery of nanoparticles and biologics across the blood-brain barrier, alongside the development of in vitro blood-brain barrier models, including stem cell-derived and microfluidic systems.
Seminars
This workshop aims to dive into the strengths and limitations of various in vitro to in vivo models (PDX, syngeneic, humanized mice, organoids) for predicting ADC performance and addressing the movement toward new alternative methodologies and better understanding of PKPD dynamics to evaluate safety and efficacy.
Key Questions:
- How do we select the right animal model for each ADC programme?
- What are the best practices for translating mouse efficacy to human dose?
- How can organoids and MPS systems complement or replace animal studies?
