Charles Dumontet
Deputy Director & Investigator Cancer Research Centre of Lyon
Kurt Pike is a highly experienced Drug Hunter and Medicinal Chemist who currently holds the role of Senior Director, External Innovation in J&J Innovative Medicines. Located at the EMEA Innovation Centre in London UK, Kurt is looking to connect with Entrepreneurs and Innovators to identify future collaboration opportunities, aligned with J&J’s strategic focus, to bring forward innovative new therapies to transform human health.
Kurt has worked in the Pharmaceutical Industry for ~30 years and has significant experience in both BD / External Innovation roles (~10 years, across both J&J and AstraZeneca) and as a Medicinal Chemist (>20 years, AstraZeneca). In these roles he has executed multiple collaboration & licensing deals and led internal Chemistry efforts resulting in the delivery of multiple clinical candidates across different therapy areas.
Seminars
This workshop aims to dive into the strengths and limitations of various in vitro to in vivo models (PDX, syngeneic, humanized mice, organoids) for predicting ADC performance and addressing the movement toward new alternative methodologies and better understanding of PKPD dynamics to evaluate safety and efficacy.
Key Questions:
- How do we select the right animal model for each ADC programme?
- What are the best practices for translating mouse efficacy to human dose?
- How can organoids and MPS systems complement or replace animal studies?
