Enlarging the Therapeutic Window: A Novel Stepwise-Cleavage Linker for Next-Generation MMAE ADCs
11:30 am - Monday 8th March 2027
- Discovering a novel linker technology to broaden the therapeutic window for MMAE-based ADCs, tackling the long-standing challenge of pairing this highly potent payload with an acceptable safety margin
- Comparing data against traditional MMAE linker chemistries, benchmarking efficacy and toxicity outcomes across pipeline
- Uncovering early progress toward dual-payload format, unlocking toxicity margin associated to combination with traditional ADC payloads