Designing the Next Generation of Cytotoxic & Non-Cytotoxic Warheads

This workshop is your opportunity to dive into emerging payload classes beyond traditional TOPO1 and microtubule inhibitors, including ATR inhibitors, immunostimulatory agents, PROTACs, and photosensitisers. Participants will discuss payload chemistry, structure-activity relationships, and strategies to overcome resistance.

Key Questions:

• Delving into ADC bioconjugation – what is the chemistry behind building ADCs?
• What are the key learnings from failed novel payload programmes?
• How do we balance payload chemistry with acceptable toxicity profiles and overcome the resistance challenge?

Workshop Leader to Be Confirmed