Auristatin S: Developing an Auristatin Payload with Improved Tolerability & Modified Bystander Activity

• Rationally designing Auristatin S to improve tolerability of auristatin payloads through the tuning of permeability and bystander activity
• Explaining how Auristatin S maintains key auristatin properties including strong tubulin binding affinity and induction of immunogenic cell death
• Exploring Austin S improved preclinical therapeutic window

Speakers:

Philip Moquist

Director, ADC Chemistry

Pfizer