Francisco Velazquez
Senior Director, Chemistry Abzena
Francisco has extensive experience in the biopharmaceutical industry, supporting clients to streamline and advance their development programs in the areas of complex chemistry and polymers, ADCs, AOCs, immuno-oncology, and other innovative approaches for the treatment of cancer.
Seminars
Tuesday 24th February 2026
Development of a Site Specific & Versatile Conjugation Approach Based on Bacterial Transglutaminase & the Diels-Alder Cycloaddition Reaction
11:30 am
- Re-purposing maleimides for conjugation to antibodies, a different application that specifically conjugates via cycloaddition reaction
- Exploring design and synthesis of diene-containing linkers for site-specific transglutaminase conjugation, with modulation for dual-payload ADCs
- Evaluating in vitro and in vivo activity and assessing stability of ADCs
- Highlighting the importance of collaborations with CROs for discovering and developing novel linker and conjugation technologies
