Two Targets, Two Hits, One Solution: The Next Generation of Bispecific, Dual Payload ADCs
- Explaining how bispecific ADCs improve efficacy by engaging two antigens, reducing the risk of escape from antigen loss or tumour heterogeneity
- Pursuing a “Two-Hit” Approach: Combining complementary payloads (e.g., DNA-damaging + DDRi) to deliver a “two-hit” attack, heightening tumour kill and resistance barriers
- Optimising bispecific ADC dual binding to improve tumour specificity, internalisation, and safety by balancing antigen engagement