TME-Specific Payload Release: Discovery & Preclinical Validation of a Novel Enzyme-Cleavable Linker

  • Addressing tumour heterogeneity and drug penetration challenges with internalisation-independent payload release
  • Screening and identifying a unique linker using a specific TME enzyme expressed across cancer models for next-generation ADC development
  • Achieving superior efficacy and safety with an internalisation-independent linker-payload system in ductal and squamous carcinoma cell lines