Contrasting Discovery & Preclinical Head‑to‑Head Comparison of Two ADCs
- Pharmaron’s fully integrated ADC platform enables comprehensive discovery and preclinical characterisation
- Direct comparison of SG and Dato‑DXd with pH‑sensitive and protease‑specific linkers, respectively
- Assessment of how linker‑driven payload release influences efficacy, in vitro and in vivo bystander effects, dosing, and safety
- Complete physicochemical, structural, in vitro, in vivo, DMPK, and toxicology assessment