Exploring an Advanced Human Skin Research Platform Enabling Long-Term & Immune-Competent Evaluation of ADC-Induced Cutaneous Toxicity
- Overviewing advanced ex vivo skin platform with demonstration of native structure maintenance and immune competence for long-term culture (~1 month) across diverse human donors
- Exploring recapitulation of ADC-induced cutaneous toxicity in human skin tissue with mechanistic insight and testing of clinical mitigation strategies
- Laying out translational screening tool to de-risk ADCs and biologics for dermatologic safety earlier in development