Implementing Rodent Models for Payload Characterisation to Support Discovery Screening & Inform Preclinical Species Relevance for ADC Safety Profile Translation
- Recapitulating clinically relevant ADC toxicity in an acute rodent IV infusion model to increase efficiency and reduce costs within payload discovery screening
- Utilising infusion models to better understand potential species-specific sensitivities to ADC toxicities
- Giving merit for infusion models to inform anticipated ADC payload PK exposures, respective of SOC or comparator drugs, to aid risk benefit analysis for ADC approaches