Contextualising Preclinical & Translational Development of ADC-C9: A Pan-Cancer Anti-ofCS ADC with Monovalent IgG Design

  • Outlining development journey finetuning an ADC for an abundant pancancer that is expressed on both stromal cells and cancer cells
  • Spotlighting unique design of ADC-C9 with monovalent IgG format (single armed IgG, scfv-fc) and a homogenous DAR2 through hinge region mutations
  • Delving into ADC-C9 preclinical safety and efficacy profile and clinical Phase 0 findings to lay out lessons learned for translation of an ADC for a novel target