Auristatin S: Developing an Auristatin Payload with Improved Tolerability & Modified Bystander Activity

  • Rationally designing Auristatin S to improve tolerability of auristatin payloads through the tuning of permeability and bystander activity
  • Explaining how Auristatin S maintains key auristatin properties including strong tubulin binding affinity and induction of immunogenic cell death
  • Exploring Austin S improved preclinical therapeutic window