Horst Bierau

Horst Bierau

Company: Merck KGaA

Job title: Senior Scientific Advisor – Head CMC Science & Intelligence

Seminars:

Live Discussion & Question Time 2:30 pm

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day: Track C - Day 1 PM

The Formidable Challenge of Controlling High Mannose-Type N-Glycans in Therapeutic mAbs 1:50 pm

Glycosylation is a critical quality attribute for mAbs because their clinical efficacy and safety are significantly affected by their glycosylation profile As opposed to endogenous IgGs, marketed therapeutic mAbs contain higher levels of high mannose glycans, which can affect efficacy, pharmacokinetics, and stability Discussing how current trends in biopharmaceutical manufacturing, such as process intensification and…Read more

day: Track C - Day 1 PM

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