Use of Design of Experiments to Define Manufacturing Process Conditions for an ADC

Time: 2:45 pm
day: Track D - Day 1 - PM


  • Explore the use of design of experiments (DOE) to understand the impact of process parameters at the reactive stages on an ADC product quality attributes
  • A 2^4 full factorial design was performed and the results were analysed via the MODDE® software, with Drug to Antibody ratio (DAR) results shown
  • Review how the software enabled identification of safe manufacturing set points for the process parameters