Understand the Effect of Conjugation Site & Technique on the Stability & Pharmacokinetics of Antibody- Drug Conjugates

Time: 11:45 am
day: Track A - Day 1 - AM


  • Review the characterisation of ADCs that were conjugated by different conjugation methods to different conjugation positions by multiple in vitro assays
  • Evaluate ADCs in vivo for conjugate stability and pharmacokinetic (PK) behavior in transgenic Tg276 mice
  • Review the ADC variants regarding in vitro assay and in vivo PK properties