Quantitative Evaluation of Relation Between Antigen Expression & ADC Exposure in Solid Tumours

Time: 12:30 pm
day: Track B - Day 2


  • Preclinical investigation of the effect of target expression level on ADC exposure in cancer cells and tumours using anti-HER2 Trastuzumab-VC-MMAE tool ADC
  • Evaluate the usage of cell level and in-vivo mechanistic ADC PK model to characterise preclinical data and the establishment of a quantitative relationship between antigen expression level and ADC exposure in a tumour
  • Understand the importance of target expression assessment for clinical success of ADCs