Predicting Successful ADC Candidates Using Combined In Vivo Data & Computational Approaches

Time: 2:15 pm
day: Track B - Day 1 - PM


  • Discussing how Antibody Drug Conjugates (ADCs) are complex drugs requiring a combination of small molecule, linker, and antibody optimisation for adequate safety and efficacy
  • Highlighting how animal data and in vitro experiments provide insight into isolated pieces of ADC design, which can be misleading without integrating the results for optimal clinical efficacy
  • Demonstrating how combined animal data and computational approaches can predict ADC design for a maximum therapeutic window including why currently approved ADCs are successful and others failed