Overcoming Immunotherapy Resistance: Targeting the Tumour Microenvironment

Time: 11:20 am
day: Track B - Day 2 AM


  • Most solid tumour types contain aggressive subgroups rich in cancer-associated fibroblasts
  • Cancer associated fibroblasts exclude CD8 T-cells from tumours and promote immunotherapy resistance
  • The cancer associated fibroblast phenotype is regulated by the enzyme NOX4, which can be targeted to overcome immunotherapy resistance