Development of a Novel Chemical Site-Specific ADC Conjugation Platform with Enhanced Therapeutic Window

Time: 9:30 am
day: Day Two


• Site-specific technologies are being employed in many of the next generation ADCs due to enhanced biological properties in pre-clinical studies.

• We report a new method of affinity peptide mediated regiodivergent antibody functionalization that enables the synthesis of ADCs from native IgGs in a tunable and atom-precise manner.